GPT / ALT UV Expand

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GPT / ALT UV

Conformité européenne In vitro diagnostic product

New

For “in vitro” determination of Transaminase GPT/ALT in serum or plasma.

More details

Volume12 x 16 mL
GTIN1418430155000614
Storage temperature+2 / +8 ºC
EstateLyophilized
SampleSerum, Plasma
TechniqueIFCC method
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Documentation

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PRINCIPLE

The glutamic-pyruvate transaminase (GPT), actually ALT, catalyzes the reaction between L-alanine and α-ketoglutaric acid. The pyruvic acid formed is reduced by NADH with the aid of the auxiliary enzyme LDH. The change of NADH to NAD+ produces a change in the Abs. In optimum reaction conditions the ΔAbs/min is directly related to GPT concentration in the sample.

DIAGNOSTIC USE

High values of GPT activity are found in hepatocyte necrosis, cirrhosis or obstructive jaundice. The increase of GPT enzymatic activity is more specifi c for liver damage than the ratio GOT / GPT. In viral hepatitis GPT increase is always greater than that of GOT. High levels of enzyme activity were detected in cases of myocarditis, myocardial infarction or hemolytic diseases. Single test result can not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.

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