ANTITHROMBIN III (AT III), 25 mL

PRINCIPLE

The reagent allows quantifying the level of human AT III present in the sample by comparing the turbidimetric response produced with that obtained from standard curve of known human AT III concentrations. The reagent is an antiserum anti-human AT III which reacts with the AT III of the serum giving protein aggregates. This aggregation process produces an increase in the Abs. of the system.

DIAGNOSTIC USE

The primary function is to inactivate the proteolytic enzyme thrombin, preventing uncontrolled clot formation. AT III also functions to inhibit activated proteases such as coagulation factors IX, X, XI and XII. Low levels of serum AT III are found in individuals suff ering from severe hepatic disorders and as the result of protein-losing syndrome, particularly in the protein-losing nephropathies.
Diseases accompanied by infl ammation may show elevated serum levels of Antithrombin III. Single test result can not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.