GPT / ALT UV, 12 x 16 mL

    993615



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    Conformité européenne In vitro diagnostic product

    For in vitro determination of Alanine aminotransferase GPT/ALT in serum or plasma.

    State Lyophilized
    Storage temp.  +2 / +8 ºC
    Technique IFCC Method

    Documentation

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    PRINCIPLE

    The glutamic-pyruvate transaminase (GPT), actually ALT, catalyzes the reaction between L-alanine and α-ketoglutaric acid. The pyruvic acid formed is reduced by NADH with the aid of the auxiliary enzyme LDH. The change of NADH to NAD+ produces a change in the Abs.

    In optimum reaction conditions the ΔAbs/min is directly related to GPT concentration in the sample.

    DIAGNOSTIC USE

    High values of GPT activity are found in hepatocyte necrosis, cirrhosis or obstructive jaundice. The increase of GPT enzymatic activity is more specific for liver damage than the ratio GOT / GPT.

    In viral hepatitis GPT increase is always greater than that of GOT. High levels of enzyme activity were detected in cases of myocarditis, myocardial infarction or hemolytic diseases.

    Single test result can not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.