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For in vitro diagnostic
PRINCIPLE
The study of the morphology, mobility, concentration and integrity of the spermatozoon membrane is an important component in the evaluation of semen quality. Fertility is reduced when the percentage of abnormal cells increases. The membranes of dead spermatozoa, or ones that are in the process of dying, are permeable to the stains. For this reason, this property is used to determine live spermatozoa. Given that immobile spermatozoa may be live, only supravital staining, such as that of eosin-nigrosin, may establish this difference. Eosin penetrates through the membrane of the dead spermatozoa staining them pink, while the live spermatozoa remain colourless. Nigrosin, on the other hand, outlines the profi le of the live spermatozoa in dark blue.
DIAGNOSTIC USE
Determination of live spermatozoa and their morphology in sperm samples.