C4 COMPLEMENT, 20 mL

PRINCIPLE

The reagent allows quantifying the level of human C4 Complement present in the sample by comparing the turbidimetric response produced with that obtained from a standard curve of known concentrations of human C4 Complement. The reagent is an antiserum anti-human C4 Complement which reacts with the C4 Complement of the serum giving protein aggregates. This aggregation process produces an increase in the Abs. of the system.

DIAGNOSTIC USE

The C4 Complement (C4) is an essential component for the complement activation pathways. Concentration of C4 are slightly increased by the acute infl ammatory reactions (trauma, inflammations or tissue necrosis). Concentration of C4 decreased in genetic deficiencies associated with a high prevalence of autoimmune or collagen vascular diseases, particularly Systemic Lupus Erythematosus (SLE). C4 plasma concentration also may decrease due to its consumption in the formation of immunocomplexes or in neonates. A single test result could not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.