APOLIPOPROTEIN B, 20 mL

    993406



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    Conformité européenne In vitro diagnostic product

    For in vitro determination of apolipoprotein A1 in serum or plasma.

    State Liquid
    Storage temp. +2 / +8 ºC
    Technique Immunoturbidimetric method

    PRINCIPLE

    The reagent allows quantifying the level of human apolipoprotein B present in the sample by comparing the turbidimetric response produced with that obtained from the standard curve of known concentrations of human apolipoprotein B. The reagent is an antiserum anti-human apolipoprotein B which reacts with the apolipoprotein B of the serum giving protein aggregates. This aggregation process produces an increase in the Abs. of the system.

    DIAGNOSTIC USE

    The apolipoprotein B (APO B) is the most abundant structural protein in LDL, VDLD lipoprotein and chylomicrons. The main function is to transport lipoproteins rich in triglycerides from the liver to body tissues. Since changes on APO A1 and APO B concentrations are similar to the ones in HDL and LDL on patients with coronary heart diseases, the measurement of apolipoproteins can be applied to the estimation of coronary risk. Increase in APO B concentration could be because a disorder on lipoprotein metabolism as hyperapobetalipoproteinemia, in which the concentration of APO B increase and LDL-cholesterol levels are normal. APO B concentration decreases in a betalipoproteinemia, in which the secretion of intestinal and hepatic lipoproteins rich in triglycerides is blocked. Single test result could not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.