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For quantitative in vitro determination of Ferritin by immunoturbidimetry in serum or plasma.
State | Liquid |
Storage temp. | +2 / +8 ºC |
Technique | Immunoturbidimetric method |
PRINCIPLE
Ferritin reagent consists of a suspension of polystyrene latex particles coated with human anti-ferritin. The agglutination produced by serum ferritin can be detected as increase of absorbance due to the aggregation of the sensitized particles.
DIAGNOSTIC USE
Ferritin is an iron storage protein; the serum ferritin concentration has a good correlation against the total body iron stores. In healthy subjects and in patients with either deficiency or excess of iron, serum ferritin is a reliable indicator of the iron pool that can be mobilized. On the other hand, the serum levels of ferritin are found to be elevated in patients with hepatic diseases, chronical inflammations, several types of cancer, and some types of rheumatoid arthritis. Besides the use of ferritin determination as indicator of metabolism of iron, it is used as tumour marker for therapeutic drug monitoring and indicator of evolution of certain tumours.